徐长卿为君药的中药方治疗活动期溃疡性结肠炎的临床观察

文章信息/Info

• Title:徐长卿为君药的中药方治疗活动期溃疡性结肠炎的临床观察

• 卷期:2024年22卷15期

• 作者:贺海辉1  沈  洪2

• 1.湖南省直中医医院肿瘤三科（湖南 株洲 412000）；2.江苏省中医院消化科（江苏 南京 210029

• Author(s):HE Haihui1，SHEN Hong2

• 1.Hunan Provincial Traditional Chinese Medicine Hospital，Zhuzhou 412000；Hunan，China；2.Jiangsu Hospital of Traditional Chinese Medicine，Nanjing 210029；Jiangsu，China

• 关键词徐长卿；溃疡性结肠炎；活动期；湿热内蕴证

• Keywords: Cynanchum paniculatum; Ulcerative colitis; Active stage;Inner-accumulation of damp-heat syndrome

• 摘要::目的  观察徐长卿为君药的中药方治疗活动期轻中度UC的临床疗效。方法  将60例病人随机分为试验组和对照组各30例，试验组给予徐长卿为君药的中药方口服，每日1剂，对照组给予美沙拉嗪肠溶片，每次1g，每日4次。两组疗程8周。比较两组治疗前后腹泻、脓血便、腹痛、腹胀、肛门灼热、里急后重、总体症状积分及红细胞沉降率、C反应蛋白，监测不良反应。结果  两组对患者腹泻、脓血便、腹痛、腹胀、肛门灼热、里急后重、总体症状及红细胞沉降率、C反应蛋白均有明显改善（P＜0.05），并且试验组对患者脓血便及总体症状的改善优于美沙拉嗪肠溶片（P＜0.05）。仅对照组有1例患者ALT升高。结论  徐长卿为君药的中药方治疗活动期轻中度UC是有效而安全的，并且对脓血便及总体症状的改善优于美沙拉嗪肠溶片。                                                                                                                                                                                

• AbstractObjective To observe the clinical efficacy of Cynanchum paniculatum's traditional Chinese medicine in the treatment of mild to moderate active UC.Methods: 60 patients were randomly divided into the experimental group and the control group, 30 cases in each group. The experimental group was given Cynanchum paniculatum's traditional Chinese medicine prescription orally, one dose a day, and the control group was given mesalazine enteric coated tablets, 1g each time, four times a day. The course of treatment was 8 weeks. Diarrhea, purulent stool, abdominal pain, abdominal distension, anal burning, diarrhea, ESR and CRP were compared between the two groups before and after treatment, and adverse reactions were monitored.Results:The two groups improved diarrhea, abscess stool, abdominal pain, abdominal distention, anal burning, internal and posterior weight, overall symptoms, blood sedimentation rate and C-reactive protein significantly (P < 0.05), and the improvement of the patients' blood abscess and overall symptoms in the experimental group was better than that of mesalazine enteric solution tablets (P < 0.05). ALT was increased in 1 case in the control group.Conclusion:The traditional Chinese medicine prescription based on Cynanchum paniculatum is effective and safe in the treatment of mild to moderate active UC, and it is better than mesalazine enteric coated tablets in the improvement of purulent stool and overall symptoms.

  溃疡性结肠炎(ulcerative colitis，UC)是一种主要累及直肠、结肠黏膜的慢性非特异性炎症性疾病，临床症状主要有腹泻、腹痛、黏液脓血便及里急后重等。其病程迁延，易反复发作，且部分病程长的患者会癌变，严重影响患者生活质量，被世界卫生组织列为难治性疾病。近年来，随着我国人民生活水平的提高与城市化、工业化和现代化的进程，我国人民患病率逐渐上升。但UC的西医治疗存在不少问题，例如：有相当一部分患者对氨基水杨酸类、激素和免疫抑制剂等治疗药物不敏感，药物的毒副作用等。而中医治疗具有效、简、便、廉的优势。2008-01—2015-12，我们采用徐长卿为君药的中药方口服治疗活动期轻中度湿热内蕴证UC30例，并与美沙拉嗪肠溶片口服治疗30例对照，观察临床症状（腹泻、脓血便、腹痛、腹胀、肛门灼热、里急后重）、炎症指标（红细胞沉降率、C反应蛋白）及不良反应，结果如下。