中药通过减少骨流失改善骨质疏松症的研究进展

文章信息/Info

• Title:中药通过减少骨流失改善骨质疏松症的研究进展

• 卷期:2024年22卷16期

• 作者:林玲1 向晓东1 帅波2 卢俊杰2 刘菊13

• 1.湖北中医药大学第一临床学院，湖北 武汉 430000；2.华中科技大学同济医学院附属协和医院中西医结合科，湖北 武汉 430000；3. 湖北中医药大学附属武汉市第一医院 综合医疗科，湖北 武汉 430000

• Author(s):LIN Ling1  XIANGXiaoDong1  SHUAI Bo 2   LU JunJie2  LIU Ju13

• 1.The First Clinical College of Hubei University of Traditional Chinese Medicine；2.Department of Integrated Traditional and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology；3.Wuhan First Hospital Affiliated to Hubei University of Traditional Chinese Medicine General Medical Department

• 关键词 骨质疏松症；破骨细胞；骨流失；中药；化学提取物

• Keywords:osteoporosis,osteoclasts,bone loss, traditional Chinese medicines, molecular mechanism

• 摘要:骨质疏松症（osteoporosis，OP）是一种常见的全身代谢性骨病，主要症状特征体现在患者骨量削减、骨微结构变性致使骨脆性增大。减少破骨细胞（osteoclast，OC）活性及增加其凋亡等途径以降低骨吸收是治疗OP的有效手段。相比于国际上主流抗OP药物的不良反应，中草药提取物具有副作用小，作用靶点广的优势，更适合用于骨质疏松的长期预防及治疗。此文通过归纳破骨细胞介导的骨吸收分子机制，及常见抗骨质疏松的中药提取物单体。对未来抗骨质疏松症新药的研发提供更多的解决思路和治疗方案。                                                                                                                                                                                

• AbstractOsteoporosis (OP) is a common systemic metabolic bone disease, characterized by bone loss and bone microstructural degeneration, resulting in increased bone fragility. Reducing osteoclast (OC) activity and increasing apoptosis to reduce bone resorption is an effective means to treat OP. Compared with the adverse reactions of mainstream anti-OP drugs in the world, Chinese herbal extracts have the advantages of small side effects and wide targets, and are more suitable for the long-term prevention and treatment of osteoporosis. In this paper, the molecular mechanism of osteoclast-mediated bone resorption and the common anti-osteoporosis traditional Chinese medicine extract monomer were summarized. Provide more solutions and treatment options for the research and development of new anti-osteoporosis drugs in the future.

  骨质疏松症主要症状特征体现在患者骨量削减、骨微结构变性致使骨脆性增大，导致脊柱、股骨及腕关节骨折风险增加，甚至增加了残疾、死亡的风险[1]。近几年，全球人口老龄化明显加速，OP患者不断增加。因此，改善OP现状并降低脆性骨折的发生率，成为了全球性公共卫生的一项重大挑战。