加味温胆汤治疗小儿幽门螺杆菌相关性胃炎临床观察

文章信息/Info

• Title:加味温胆汤治疗小儿幽门螺杆菌相关性胃炎临床观察

• 卷期:2024年22卷16期

• 作者:陈红梅   高诗晴   林洁琪   程志涣  阮灵秀  陈辉清

• 福建省福州儿童医院中医科，福建 福州 350005

• Author(s):Hongmei Chen,Shiqing Gao,Jieqi Lin，Zhihuan Cheng，Linxiu Ruan，Chen

• Fuzhou Children's Hospital traditional Chinese medicine department ,Fujian，Fuzhou,350005

• 关键词幽门螺杆菌相关性胃炎；小儿；中西医结合；临床观察

• Keywords:HPAG；children；Integrated traditional Chinese and western medicine；Clinical observation

• 摘要:目的 观察加味温胆汤联合西药治疗HPAG的疗效。方法  选取中医科门诊符合HPAG诊断患儿100例，随机分为治疗组和对照组。对照组50例用奥美拉唑肠溶胶囊、阿莫西林胶囊、克拉霉素片口服治疗；治疗组在西药基础上加用中药加味温胆汤颗粒剂。观察各组治疗前和治疗2周后的胃炎症状变化，停药4周后HP清除率。结果  治疗后腹部胀满疼痛无差异，口干口苦、纳差、恶心呕吐、嗳气反酸、便秘等主要临床症状改善率，治疗组优于对照组，两组间比较，差异有统计学意义(P<0.05）。Ｈｐ清除率治疗组转阴45例（90％），对照组42例（84％），两组比较差异有统计学意义(P<0.05）。                                                                                                                                                                                

• Abstract  Objective To observe the curative effect of Jiawei Wendan decoction combined with western medicine in the treatment of HPAG.Methods：100 children with HPAG were randomly divided into treatment group and control group.The control group was treated with omeprazole enteric capsules, amoxicillin capsules and clarithromycin tablets；On the basis of western medicine, Wendan decoction granule was added in the treatment group.The changes of gastritis symptoms before and after 2 weeks of treatment, and HP clearance rate after 4 weeks of drug withdrawal were observed in each group.Result: After treatment, there was no difference in abdominal distension and pain, dry mouth, poor appetite, nausea and vomiting, belching and acid regurgitation, constipation and other main clinical symptoms improved.The treatment group was better than the control group, the difference between the two groups was statistically significant(P<0.05）.Hp clearance rate of 45 cases (90%) in the treatment group, 42 cases (84%) in the control group, the difference was statistically significant (P<0.05).

  幽门螺杆菌(Helicobacter pylori，Hp)为革兰阴性菌，是一种微需氧型菌，儿童胃炎中HP阳性率约为40％~60％[1] ，并以每年1%~0.5%的速度递增[2]，属于祖国医学“胃院痛”“吐酸”等范畴。我院中医门诊采用中西医治疗，取得了满意疗效。