参苓健脾饮治疗脾虚湿盛型慢性乙型病毒性肝炎的临床研究

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• Title:参苓健脾饮治疗脾虚湿盛型慢性乙型病毒性肝炎的临床研究

• 卷期:2024年22卷17期

• 作者:张金付

• 福建中医药大学附属三明市中西医结合医院感染科，福建三明，365001

• Author(s):Jinfu Zhang

• Sanming Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Fujian University of Traditional Chinese Medicine, Sanming 365001, China

• 关键词参苓健脾饮；脾虚湿盛；慢性乙型病毒性肝炎

• Keywords:Shenling Jianpi Decoction;Spleen Deficiency and Dampness Excess;Chronic Hepatitis B

• 摘要:目的: 观察参苓健脾饮治疗脾虚湿盛型慢性乙型肝炎患者的临床疗效及对肝功能及HBVDNA、Fibroscan的影响。方法:70例脾虚湿盛型慢性乙型肝炎患者随机平均分为2组，对照组予以保肝、降酶、抗病毒治疗，治疗组在对照组的基础上予以参苓健脾饮治疗。治疗3个月后观察两组患者中医证候评分、肝功能、Firoscan、HBVDNA等情况。结果：治疗后治疗组中医证候评分、肝功能、Firoscan均低于对照组（P＜0.05）。结论：参苓健脾饮联合恩替卡韦分散片在改善脾虚湿盛型慢性乙型肝炎患者中医证候、肝功能、肝硬度值方面优于单用恩替卡韦分散片。                                                                                                                                                                                

• Abstract To observe the clinical efficacy of Sheniling Jianpi Decoction in the treatment of chronic hepatitis B with spleen deficiency and dampness excess and its effect on liver function, HBV DNA and Fibroscan.Methods:70 cases of chronic hepatitis B patients with spleen deficiency and dampness excess were randomly divided into two groups,the control group was treated with liver protection, enzyme reduction and antiviral treatment,the treatment group was treated with Shenling Jianpi Decoction on the basis of the control group. After 3 months of treatment, observe the two groups of patients TCM syndrome score, total effective rate, liver function,Fibroscan,HBV DNA,etc.Results:After treatment, the TCM syndrome score, liver function, Fibroscan in the treatment group were lower than those in the control group (P < 0.05).Conclusions:Shenling Jianpi Decoction combined with entecavir dispersible tablets is better than entecavir dispersible tablets alone in improving TCM syndrome, liver functionand liver hardness in patients with chronic hepatitis B of spleen deficiency and dampness excess.

  慢性乙型肝炎（Chronic hepatitis B，CHB）是乙型肝炎病毒（Hepatitis B virus，HBV）感染了人体，且病毒持续存在人体超过6个月的一种肝脏慢性炎症性疾病。据我国疾病预防控制中心近5年的数据，每年报告传染病发病数在所有传染病病种中病毒性肝炎排第一，死亡率在所以传染病中排第三或第四，而无论发病率还是死亡率乙型肝炎在所有病毒性肝炎中均占77%以上。