炙甘草汤治疗蒽环类药物相关性室性心律失常

文章信息/Info

• Title:炙甘草汤治疗蒽环类药物相关性室性心律失常

• 卷期:2024年22卷19期

• 作者:邢晶晶1，李鸿真2，庄欣3▲ 杨洁3

• 1.山东中医药大学第一临床医学院，山东济南，250014;2. 山东省第二人民医院麻醉科，山东济南，250014;3.山东中医药大学附属医院心内科，山东济南，250014

• Author(s):XING Jingjing  LI Hongzhen  ZHUANG Xin  YANG Jie

• 1. The First Clinical College of Medicine, Shandong University of Traditional Chinese Medicine; 2. Department of Anesthesiology, the Second People's Hospital of Shandong Province;; 3. Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

• 关键词炙甘草汤；心悸；室性心律失常；蒽环类药物

• Keywords:Grilled licorice soup; Palpitation; Ventricular arrhythmia; Anthracyclines

• 摘要: 蒽环类药物（Anthracyclines，ANT）相关性室性心律失常是肿瘤患者因使用蒽环类药物抗肿瘤治疗而产生的剂量性心脏毒性引起的不良反应，但目前对于使用ANT所引起的室性心律失常暂无有效的的治疗及预防措施，故成为如今肿瘤心脏学科领域关注的重点。传统中医药文化历史悠久，有着丰富的理论和经验总结。目前，临床上采用中西医结合治疗肿瘤患者的方法对于减轻ANT所导致的心脏毒性取得了较好的疗效。中医药干预ANT所致的心脏毒性具有较为重要的临床意义。根据本病临床症状归为中医“心悸”范畴，运用经典名方炙甘草汤治疗，可减少或缓解肿瘤患者在使用ANT化疗后出现药物相关性室性心律失常，改善临床症状。                                                                                                                                                                                

• AbstractAnthracyclines (ANT) -associated ventricular arrhythmias are adverse reactions caused by dose cardiotoxicity caused by anthracyclines in tumor patients. However, there is currently no effective treatment or preventive measure for ventricular arrhythmias caused by ANT. Therefore, it has become the focus of attention in the field of oncology and cardiology. Traditional Chinese medicine culture has a long history, rich theory and experience summary. At present, the combination of traditional Chinese and western medicine in the clinical treatment of tumor patients has achieved a good effect in alleviating the cardiotoxicity caused by ANT. The intervention of traditional Chinese medicine in cardiotoxicity caused by ANT has important clinical significance. According to the clinical symptoms of this disease classified into the category of "palpitation" of traditional Chinese medicine, the treatment with the classic prescription Zhigao decoction can reduce or relieve drug-related ventricular arrhythmias in tumor patients after ANT chemotherapy, and improve the clinical symptoms.

  随着肿瘤学、分子生物学等相关学科的发展以及中西医结合治疗肿瘤的大量临床经验总结，肿瘤患者的临床治疗研究不仅在方法和靶点上有了新突破，而且对于中晚期肿瘤患者的生存期延长有着不断的收获。但是由于抗肿瘤药物疗效的不确定性以及各种不良反应逐步显现，肿瘤的临床治疗仍然存在困难。肿瘤患者化疗方案也会造成机体其他器官不同程度的损伤，其中心血管方面的副作用是最不可忽视的，并且是与化疗相关性发病率和病死率的主要原因[1]。