中医治疗非甾体抗炎药相关消化系统不良反应的研究进展

文章信息/Info

• Title:中医治疗非甾体抗炎药相关消化系统不良反应的研究进展

• 卷期:2024年22卷20期

• 作者:李有强 徐阳✉

• 天津中医药大学第一附属医院、国家中医针灸临床医学研究中心，天津，300380

• Author(s):LI Youqiang

• First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300380, China

• 关键词中医；非甾体抗炎药相关不良反应；消化系统

• Keywords: traditional Chinese medicine; adverse reactions of Nonsteroidal Anti-inflammatory Drugs; digestive system

• 摘要:非甾体抗炎药（NSAIDs）相关不良反应发生率高，可导致人体诸多系统损伤，以胃肠道系统组织损伤最为常见。中医药治疗NSAIDs相关消化系统不良反应具有疗效确切、安全性高、针对性强等优点，能很大程度减轻患者不适，提高患者的生存质量。文章从传统医学经典理论、名家经验、临床研究、基础研究等方面对近年中医药在NSAIDs相关消化系统不良反应治疗中的研究进行综述，以期为该病未来的研究及临床治疗提供参考依据，探寻中医药缓解药物不良反应的治疗方法并发挥中医药诊疗疾病的优势。                                                                                                                                                                                

• Abstract The incidence of the adverse reactions resulted from Nonsteroidal Anti-inflammatory Drugs(NSAIDs) is of high ratio， which can influence many systems in the human body， and the damage to the digestive system is the most common. Traditional Chinese medicine treatment for the adverse reactions of the digestive system resulted from NSAIDs has the advantages of precise curative effect， high safety and accuracy， it can also greatly reduce the discomfort and improve the patients’ quality of life. The author reviews the recent research of traditional Chinese medicine treatment for adverse reactions of NSAIDs from the aspects of classical theories of traditional Chinese medicine， famous doctors’ medical experience， clinical trials and basic experiments. In order to provide a reference for future research and treatment of the disease， and explore the traditional Chinese medicine therapy for alleviate adverse drug reactions and give full play to the advantages of traditional Chinese medicine.

  非甾体抗炎药（NSAIDs）适应症和用途广泛，临床常用于抗炎、抗血小板聚集、解热、镇痛及抗肿瘤等治疗[1]，是当前处方量最大的药物之一，占全球处方量的7.7%。长期或大剂量服用非甾体抗炎药在治疗原发病的同时会出现多种不良反应，以胃肠道组织损伤导致消化系统功能紊乱最为常见。其表现为消化不良、恶心、呕吐、腹痛、腹泻等，甚致引发溃疡、出血、穿孔，严重者可危及生命。据统计全球每年NSAIDs相关胃肠道事件导致的住院病例数量高达65万例，死亡例数达16.5万例[2]。我国相关临床研究中，一项5597例NSAIDs相关不良反应报告分析[3]显示，引起NSAIDs相关不良反应例数排名前3位的药物分别为氟比洛芬酯、阿司匹林、丙帕他莫，累及系统最多的是胃肠系统，占比26.02%，且不良反应发生率随年龄增长而升高。