改善子宫内膜容受性的临床治疗述评

文章信息/Info

• Title:改善子宫内膜容受性的临床治疗述评

• 卷期:2023年21卷24期

• 作者:丁申奥1  张亚迪1  王常海2※  杜梓臻2  杜志欣1  刘岳轩1  梁绿圆3

• 1.河南中医药大学医学院，河南 郑州 450000；2.河南中医药大学中医学院（仲景学院），河南 郑州 450000；3.河南中医药大学儿科医学院，河南 郑州 450000

• Author(s):Ding Shenao1  Zhang Yadi1  Wang Changhai2※  Du Zizhen2  Du Zhixin1  Liu Yuexuan1  Liang Lvyuan3

• 1. College of Medicine, Henan University of Traditional Chinese Medicine, Henan Province, Zhengzhou 450000, China;2. College of Traditional Chinese Medicine, Henan University of Traditional Chinese Medicine, Zhongjing College,Zhengzhou 450000, China；3. College of Pediatrics, Henan University of Traditional Chinese Medicine,Zhengzhou 450000, China

• 关键词子宫内膜容受性；不孕症；妊娠结局；辅助生殖技术；中西医治疗

• Keywords:Endometrial receptivity；Infertility；Pregnancy outcome；Assisted reproductive technology；Traditional Chinese and western medicine treatment

• 摘要: 不孕不育症已成为影响人类健康的重大问题，促进人口长期均衡增长关乎到中华民族未来的发展。虽然现代辅助生殖技术已经相对成熟，但受孕率仍然很低。胚胎顺利着床和提高妊娠率的关键是提高子宫内膜容受性。怎样改善子宫内膜容受性，提高胚胎的着床率使内膜与胚胎发育水平趋于一致，进而来提高临床妊娠率，是目前人类医学生殖探讨的重难点问题。本文综述了近年来中、西医药在改善子宫内膜容受性方面取得的成就，以期能够为提高妊娠成功比例提供临床帮助。                                                                                                                                                                                

• Abstract:Infertility has become a major problem affecting human health, and promoting long-term balanced population growth is linked to the future development of the Chinese nation. Although modern assisted reproductive technology is relatively mature, the pregnancy rate is still very low. The key to smooth embryo implantation and increase pregnancy rate is the improvement of endometrial receptivity. How to improve the receptivity of endometrium, increase the implantation rate of embryo, make the advance level of endometrium and embryo tend to be the same, and then improve the clinical pregnancy rate, which is the key and difficult problem of human medical reproduction. This paper summarizes the achievements of Chinese and western medicine in improving endometrial receptivity in recent years, in order to provide clinical help for increasing the success rate of pregnancy.

  不孕症发病率正在持续上升，人类辅助生殖技术(Assisted Reproductive Technology，ART)可以解决一些问题，但临床妊娠率仍较低。不孕患者胚胎着床失败主要由于胚胎本身的发育问题与子宫内膜容受性的功能障碍。研究表示，子宫内膜容受性因素占ART失败原因的2/3[1]。