补阳还五汤治疗偏头痛临床疗效的干预性meta分析

文章信息/Info

• Title:补阳还五汤治疗偏头痛临床疗效的干预性meta分析

• 卷期:2023年21卷24期

• 作者:张雅萱1，张文静1，刘梦1，郭闫葵2

• 1.山东中医药大学中医学院，山东济南，250014；2.济南市中医医院脑病科，山东济南，250014

• Author(s):ZHANG Yaxuan1,ZHANG Wenjing1,LIU Meng1,GUO Yankui2

• 1. College of traditional Chinese medicine，Shandong University of Traditional Chinese Medicine 2. Encephalopathy department，Jinan Municipal Hospital of Traditional Chinese

• 关键词补阳还五汤；偏头痛；随机对照试验；meta分析

• Keywords:Buyang Huanwu Decoction; Migraine; Randomized controlled trial; Meta-analysis

• 摘要:目的：通过meta分析系统地评价补阳还五汤治疗偏头痛的临床疗效。方法：从数据库中检索自建库至2022年2月间与本研究相关的临床随机对照试验（RCT）的文献。进行文献筛选和数据提取后，对纳入的研究使用RevMan5.3软件处理分析。结果：RR=1.25，95%CI为[1.20，1.31]，Z=9.67，P<0.00001，提示补阳还五汤组与常规西药组临床疗效的差异具有统计学意义，运用补阳还五汤治疗偏头痛的临床效果好于常规西药的治疗。漏斗图左右大致对称，提示存在发表偏倚的风险比较低。结论：运用补阳还五汤治疗偏头痛比常规西药治疗更具优势。                                                                                                                                                                                

• Abstract: To systematically evaluate the clinical efficacy of Buyang Huanwu Decoction in the treatment of migraine by meta-analysis. METHODS: The database was retrieved from the database for the literature of clinical randomized controlled trials (RCTs) related to this study between the establishment of the database and February 2022. After literature screening and data extraction, the included studies were processed and analyzed using RevMan5.3 software. Results: RR=1.25, 95%CI was [1.20, 1.31], Z=9.67, P<0.00001, suggesting that the difference in clinical efficacy between Buyang Huanwu Decoction group and conventional western medicine group was statistically significant. The clinical effect of treating migraine is better than that of conventional western medicine. The funnel plot is roughly symmetrical from left to right, suggesting a low risk of publication bias. Conclusion: The use of Buyang Huanwu Decoction in the treatment of migraine has more advantages than conventional western medicine treatment.

  偏头痛的西医病机尚不明确，目前认为其发生与遗传、环境、内分泌和情绪等因素有关。因其发作时间不定、疼痛剧烈、迁延难愈，且常伴有恶心、呕吐、心烦等，对患者造成严重的困扰。且偏头痛患者发生卒中、心绞痛等疾病的几率明显高于正常者[1]。提高偏头痛的疗效已经成为临床中亟待解决的问题。西医以对症治疗为主，虽可暂缓头痛的症状，但疗效并不彻底，亦存在诸多不良反应。