鹿角脱盘物质基础及药理研究进展

文章信息/Info

• Title:鹿角脱盘物质基础及药理研究进展

• 卷期:2023年21卷24期

• 作者:李振宇1,4，马佰偏2,3

• 1.黑龙江康尔泰克生物科技有限公司，黑龙江哈尔滨 150028；2.漠河五行健生物科技有限公司，黑龙江漠河 165399；3.哈尔滨圣源生物工程有限公司，黑龙江哈尔滨 1500284；4.黑龙江北野龙医药科技有限公司，黑龙江哈尔滨 150036

• Author(s):LI Zhen-yu 1, 4,MA Bai-pian 2,3

• 1. Heilongjiang kangertaike Biotechnology Co., Ltd., Harbin 150028, China; 2. Mohe wuxingjian Biotechnology Co., Ltd., Mohe 165399, China; 3. Harbin Shengyuan Bioengineering Co., Ltd., Harbin 150028, China;4. Heilongjiang beiyelong Pharmaceutical Technology Co., Ltd., Harbin 150036, China

• 关键词鹿角脱盘；物质基础；药理；研究进展

• Keywords:Deer antler base; material basis; pharmacology; research progress

• 摘要:鹿角脱盘作为鹿茸、鹿角的附属产物，一直以来未得到有效的开发利用，致使浪费较大。其历年来被《中国药典》按中药材鹿角收载，但实际二者之间的物质基础、药理毒理等差别较大，不能混为一谈。鹿角脱盘的主要活性成分为多肽类，未来的研究方向为靶向生物小分子多肽方向，本研究认为鹿角脱盘多肽对乳腺癌、乳腺增生、乳腺炎及骨质疏松等疾病的治疗效果较佳，目前市面上尚无鹿角脱盘相关产品，尤其建议研发鹿角脱盘多肽缓控释乳房透皮吸收制剂及相关医疗器械等。根据乳腺疾病及骨质疏松症治疗药物的发展现状及前景分析，市场潜力较大。                                                                                                                                                                                

• Abstract: As an accessory product of pilose antler and antlers, deer antler base has not been effectively developed and utilized, resulting in great waste. It has been recorded in the Chinese Pharmacopoeia according to the antlers of traditional Chinese medicine for many years, but the material basis, pharmacology and toxicology of the two are quite different, so they can not be confused. The main active ingredient of deer antler base is polypeptide, and the future research direction is to target biological small molecular peptides.This study considers that deer antler basepolypeptide has better therapeutic effect on breast cancer, breast hyperplasia, mastitis, osteoporosis and other diseases. At present, there is no deer antler baserelated products on the market, and it is especially recommended to develop deer antler base polypeptide with slow and controlled release Skin absorption preparations and related medical devices, etc. According to the development status and Prospect of drugs for breast disease and osteoporosis, the market potential is great.

  鹿角脱盘，又名鹿角帽、鹿角盘、鹿花盆，为马鹿、梅花鹿取茸后次年春自然脱落的角基，性温、味咸、归肾肝经、无毒，《神农本草经》记载：“主恶疮痈肿，逐邪恶气，留血在阴中”，历来被《中国药典》按鹿角收载[39]，但长久来它一直未得到良好的开发利用，仅为初加工产品，主要为粉碎后直接配伍使用，民间经验方多采用鹿角脱盘治疗乳腺疾病，疗效较好。