早发性卵巢功能不全中医药研究概况

文章信息/Info

• Title:早发性卵巢功能不全中医药研究概况

• 卷期:2024年22卷1期

• 作者:范敏1 于潇2  张丽娟1✉

• 1.山东中医药大学中医学院，山东 济南 250014；2.山东中医药大学附属医院妇科，山东 济南 250014

• Author(s):Fan Min1 Yu Xiao2 Zhang Lijuan 1✉

• 1. The first clinical medical college of Shandong University of traditional Chinese medicine, Jinan, Shandong, 250014 2. Department of Gynecology, Affiliated Hospital of Shandong University of traditional Chinese medicine, Jinan, Shandong, 250014

• 关键词早发性卵巢功能不全；病因病机研究；中医药治疗

• Keywords:Premature ovarian insufficiency; Study on etiology and pathogenesis; Traditional Chinese medicine treatment

• 摘要:早发性卵巢功能不全（POI）是卵巢功能逐渐衰退的其中一个阶段，西医对于本病发病机制尚不明确，治疗采用激素替代治疗（HRT）及辅助生殖技术（IVF-ET），诸多副作用、治疗周期长及费用昂贵等因素使中医药在本病的治疗中获得了诸多患者的青睐。笔者将近年来POI病因病机、中医药治法及中药临床实验研究进行归纳总结，以期为未来治疗本病提供思路和依据。                                                                                                                                                                                

• Abstract:Premature ovarian insufficiency (POI) is one of the stages of gradual decline of ovarian function. Western medicine is not clear about the pathogenesis of this disease. Western medicine adopts hormone replacement therapy (HRT) and assisted reproductive technology (IVF-ET). Many side effects, long treatment cycle and high cost make traditional Chinese medicine favored by many patients in the treatment of this disease.The author summarizes the etiology and pathogenesis of POI, traditional Chinese medicine treatment and clinical experimental research of traditional Chinese medicine in recent years, in order to provide ideas and basis for the treatment of this disease in the future.

  POI是指女性在40岁以前出现卵巢功能减退，主要表现为月经异常（闭经、月经稀发或频发）、促性腺激素水平升高[卵泡刺激素（FSH)>25 U/L]、雌激素水平波动性下降，POI是卵巢功能逐渐衰退的其中一个阶段，而POF为该病的终末阶段[1]。有研究表明POI影响约1%的女性，目前该病病因及病理机制尚不明确，根据已知的病因分为遗传性、医源性、自身免疫性、环境因素。POI主要临床表现为月经异常、不孕及潮热盗汗、失眠、烦躁等围绝经期症状。