下肢洗剂对膝关节骨性关节炎治疗作用的研究

文章信息/Info

• Title:下肢洗剂对膝关节骨性关节炎治疗作用的研究

• 卷期:2024年22卷1期

• 作者:于强，李伟铭，徐明亮，赵森*

• 大连大学附属中山医院中医科，辽宁 大连 116001

• Author(s):YU QIANG, LI Wei-ming, XU Ming-liang, ZHAO Sen*

• Affiliated Zhongshan Hospital of Dalian University, Pharmacy department,Liaoning, Dalian,116001,China

• 关键词下肢洗剂；双氯芬酸二乙胺乳胶剂；膝骨关节炎；西安大学和麦克马斯特大学骨关节炎指数；白细胞介素-1β；白介素-6；疗效评价

• Keywords:xiazhi lotion; diclofenac diethylamine emulsion; knee osteoarthritis; WOMAC score; IL-1β; IL-6; curative effect evaluation

• 摘要:目的 探讨下肢洗剂治疗膝骨关节炎的治疗作用。方法 选择60例膝骨关节炎患者为研究对象，将其随机分成试验组和对照组各30例。对照组给予双氯芬酸二乙胺乳胶剂外用。试验组给予下肢洗剂外用熏洗。两组均持续治疗2周。观察两组的临床疗效，比较两组治疗前后西安大学和麦克马斯特大学骨关节炎指数（WOMAC）量表及血清学指标的变化情况。结果：试验组和对照组的总有效率分别为66.67%和50.00%，经统计学分析，两组数据具有统计学意义。通过治疗，两组患者的WOMAC量表各评分中，白细胞介素-1β（IL-1β）及白介素-6（IL-6）均有不同程度下降。结论：下肢洗剂对于阳虚寒凝型膝骨关节炎具有治疗作用，可以很好的改善其临床症状，使血清炎性因子降低，在临床有一定的应用推广价值。                                                                                                                                                                                

• Abstract: To investigate the therapeutic effect of lower limb lotion on knee osteoarthritis. Methods 60 patients with knee osteoarthritis were randomly divided into experimental group and control group (30 cases in each group). The control group was given diclofenac diethylamine latex for external use. The experimental group was given lower limb lotion for external fumigation. Both groups were treated for 2 weeks. The clinical efficacy of the two groups were observed, and the changes of WOMAC scale and serological indexes in xi 'an University and McMaster University before and after treatment were compared. Results The total effective rate of experimental group and control group was 66.67% and 50.00%, respectively, The data of the two groups were statistically significant. After treatment, interleukin-1 β (IL-1β) and interleukin-6 (IL-6) in WOMAC scale were decreased in 2 groups. Conclusion Lower limb lotion has definite curative effect on knee osteoarthritis patients with Yang deficiency and cold coagulation type, which can effectively improve the clinical symptoms of knee osteoarthritis and regulate the serum inflammatory factors, and has certain clinical application value.

  膝骨关节炎是一种慢性骨关节疾病，由多种因素引起关节软骨纤维化、皲裂、溃疡、脱失而导致的关节疾病。主要临床症状为关节僵硬、活动受限、疼痛等症状，在中老年群体中多发[1]。膝骨关节炎容易造成关节畸形及残疾，会给个人及社会造成很大的行动障碍及经济负担。目前临床上对于膝骨关节炎没有统一、完整的治疗方案。减轻患者疼痛，防止病情进一步恶化为主要治疗方法[2]。而膝骨关节炎患者在患病早期症状并不明显，通过药物进行保守治疗通常可以取得比较可观的疗效[3]。