小儿过敏性紫癜患儿60例临床特征分析及小儿紫癜疹消颗粒临床疗效观察

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• Title:小儿过敏性紫癜患儿60例临床特征分析及小儿紫癜疹消颗粒临床疗效观察

• 卷期:2024年22卷2期

• 作者:朱浩宇1 薛娇娇2 郭黎明2

• 1长春中医药大学附属医院儿童诊疗中心内二科，吉林 长春 130021；2长春中医药大学研究生院，吉林 长春  130117

• Author(s):Zhu Hao-yu1, Xue Jiao-jiao2, Guo Li-ming2

• 1 Ph.D., Associate Professor, Deputy Chief Physician, Master's Instructor Internal Medicine Second Department，Pediatrics Medical Center, Affiliated Hospital of Changchun University of Traditional Chinese Medicine,Changchun Jilin 130021, China；2 Pediatrics of traditional Chinese Medicine Graduate School of Changchun University of traditional Chinese Medicine Changchun Jilin 130117,  China

• 关键词小儿；过敏性紫癜；临床特征；小儿紫癜疹消颗粒；临床观察

• Keywords:children; Henoch-Schonlein purpura; clinical characteristics; Xiao’er Zidian Zhenxiao granules; clinical observation

• 摘要:目的：分析小儿过敏性紫癜患儿临床特征及观察小儿紫癜疹消颗粒临床疗效。方法：调查HSP患儿一般情况、血常规等炎症指标以及过敏原。按随机数字表法，分为对照组和治疗组，每组各30例，分别给予小儿紫癜疹消颗粒和银翘散口服，疗程7天。结果：男女比例1.14：1，年龄5-10岁，发病多见于1、2和10、11、12月份，一般炎症指标血常规、降钙素、抗O均有所上升，部分患者腺病毒、人呼吸道合胞病毒等抗体阳性，血清IgA、补体C3水平明显升高，80%HSP患儿过敏原呈阳性。对照组和治疗组有效率为73.33%和93.33%，差异有统计学意义( P<0.05) 。治疗前后症候积分对比，相差2.19±1.48分，具有明显差异。结论：男孩发病略多于女孩，5～10岁为主，秋冬季多见。炎症指标升高，可伴有病毒、肺炎支原体衣原体感染，较多患儿过敏原阳性。急性期存在体液免疫紊乱。临床证实小儿紫癜疹消颗粒治疗HSP疗效显著。                                                                                                                                                                                

• Abstract:To analyze the clinical characteristics of children with Henoch-Schonlein purpura and observe the clinical efficacy of Xiao’er Zidian Zhenxiao granules in children.Methods: Investigate the general situation, blood routine and other inflammatory indicators and allergens of HSP children and allergens. According to the random digital table, it was divided into control group and treatment group, and 30 cases each group were given, respectively, and the chills of Xiao’er Zidian Zhenxiao granules and Yinqiao granules, 7 days, compared the clinical efficacy of two groups.Results: The ratio of male to female was 1.14:1, the age was 5-10 years old, and the incidence was more common in January, February and October, November and December. The general inflammatory indicators blood routine, calcitonin, and anti-O all increased. Human respiratory syncytial virus and other antibodies were positive, serum IgA and complement C3 levels were significantly increased, and 80% of children with HSP were positive for allergens. The effective rates of the control group and the treatment group were 73.33% and 93.33%, and the difference was statistically significant (P<0.05). Comparing the symptom scores before and after treatment, the difference was 2.19±1.48 points, which was significantly different.Conclusion: The boy is in illness than girls, mainly 5 ~ 10 years old, and there is more than autumn and winter. Generally, the inflammatory indicators have increased, which can be accompanied by viruses, pneumonia-bacolid primers infections, and more allergens are allergen. There is a humoral immune disorder in the acute phase. Clinically confirmed that Xiao’er Zidian Zhenxiao granules was significant.

  过敏性紫癜（Henoch-schonlein purpura,HSP）是小儿常见的一种以小血管炎为病理改变的自身免疫性疾病。迄今为止，本病的病因和发病机制尚未完全阐明[1]，根据其疾病特征表现分为皮肤型、腹型、关节型、肾型等多种临床类型。