基于网络药理学探讨金匮肾气丸治疗慢性心力衰竭的作用机制

文章信息/Info

• Title:基于网络药理学探讨金匮肾气丸治疗慢性心力衰竭的作用机制

• 卷期:2024年22卷4期

• 作者:刘妍宏，何义鑫△，胡景璇

• 江西中医药大学 研究生院 江西南昌 330006

• Author(s):Liu Yan-hong,He Yi-xin△,Hu Jing-xuan

• Graduate School,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China

• 关键词金匮肾气丸；慢性心力衰竭；网络药理学；作用机制

• Keywords:Jingui Shenqi Pill; Chronic heart failure; Network pharmacology; Mechanism of action

• 摘要:目的 借助数据库获取金匮肾气丸与CHF交集基因。利用Cytoscape3.8.0软件构建中药化合物－靶点网络及蛋白与蛋白相互作用网络PPI，筛选出关键靶点，进行GO和KEGG通路富集分析。结果 1.获得金匮肾气丸与CHF的交集靶点190个，得到槲皮素、山柰酚等关键化合物。2.PPI分析筛选得到21个核心基因，并构建调控网络。3.GO分析得出2316条生物过程，主要与氧化应激等生物过程密切相关。4.KEGG分析获得178条相关信号通路，主要涉及AGE-RAGE、IL-17、TNF、HIF-1信号通路等。结论 金匮肾气丸主要通过多成分、多靶点、多途径作用机制治疗CHF，值得进一步研究探讨。                                                                                                                                                                                

• Abstract: To analyze the mechanism of Jinkui Shenqi Pill in the treatment of chronic heart failure (CHF) through network pharmacology. Methods The intersection genes of CHF and Jingui Shenqi Pill were obtained by database.Cytoscape3.8.0 software was used to construct TCM compound-target network and Protein Protein Interaction Network to screen out key targets,and the key targets were screened out for GO analysis and KEGG pathway enrichment analysis.Result 1.190 intersecting targets of Jingui Shenqi Pill and CHF were obtained, and key compounds such as quercetin and kaempferol were obtained. 2. 21 core genes were screened by PPI analysis, and the regulatory network was constructed. 3.According to GO analysis, 2316 biological processes are obtained, which are closely related to biological processes such as oxidative stress. 4.KEGG analysis results showed that 178 related signal pathways were obtained, mainly involving AGE-RAGE, IL-17, TNF, HIF-1 signal pathways. Conclusion Jinkui Shenqi Pill mainly treats CHF through multi-component, multi-target and multi-channel mechanism, which is worthy of further research and discussion.

  心力衰竭是各种心脏结构或功能性疾病导致心室充盈和（或）射血功能受损，心排血量不能满足机体组织代谢需要，以肺循环和（或）体循环淤血，器官、组织血液灌注不足为临床表现的一组综合征。