基于数据挖掘中医药预防大肠息肉术后复发的临床研究

文章信息/Info

• Title:基于数据挖掘中医药预防大肠息肉术后复发的临床研究

• 卷期:2024年22卷4期

• 作者:刘洪波

• 泰安市中医医院脾胃病科，山东 泰安 271000

• Author(s):Hongbo Liu

• Department of Spleen and Stomach Diseases, Tai 'an Traditional Chinese Medicine Hospital, Shandong Tai'an, 271000

• 关键词大肠息肉；健脾祛湿；清热解毒；活血化瘀

• Keywords:Colon polyp, invigorate spleen and remove dampness, heat clearing and detoxification, active blood circulation and remove stasis

• 摘要:目的 通过挖掘中医药预防大肠息肉术后复发的用药规律及治疗方法，探讨其发病机制，为结肠息肉的临床治疗提供诊治依据。方法 整理自2010年后国内公开发表的、具有明确疗效的预防结肠息肉术后复发的文献，利用古今医案平台系统V2.4.3版本进行数据统计分析与挖掘，总结相关用药规律。结果 共纳入相关文献50篇，预防大肠息肉复发中药组方50首，涉及中药173味，10次以上高频药10味，分别为茯苓、甘草、党参、白术、薏苡仁、陈皮、白花蛇舌草、乌梅、莪术、陈皮；15次以上关联药物5对，分别为党参-茯苓、白术-党参、白术-茯苓、陈皮-茯苓、薏苡仁-茯苓；得出方剂树包含以下药物：茯苓、党参、白术、陈皮、甘草、薏苡仁、山药；中药及方剂功效均以健脾、祛湿、清热、活血为主。结论 在大肠息肉发病中，脾虚为本，湿、热、瘀为标，其治疗原则以健脾祛湿为主，以清热解毒、活血化瘀为辅。                                                                                                                                                                                

• Abstract:By exploring the medication rules and treatment methods of Traditional Chinese Medicine to prevent recurrence of colon polyp after operation, the pathogenesis of colon polyp is discussed, and the diagnosis and treatment basis for clinical treatment of colon polyp is provided.Methods: Sorting out the literatures on prevention of postoperative recurrence of colon polyps with definite curative effect published in China since 2010, the data were statistically analyzed and mined using V2.4.3 version of ancient and modern medical case platform system, and the relevant medication rules were summarized.Results: A total of 50 related literatures and 50 Traditional Chinese Medicine prescriptions for preventing recurrence of colon polyps are included, there are 173 species of Traditional Chinese Medicine and ten of them are high frequency of occurrence, including poria cocus, glycyrrhiza, codonopsis, atractylodes atractylodes, coix seed, tangerine peel, oldenlandia diffusa roxb, dark plum. There are five pairs of fifteen times associated drugs, including codonopsis - poria, atractylodes macrocephala - codonopsis, atractylodes atractylodes - poria cocos, tangerine peel - poria cocos, coix seed - poria cocos. The formula tree contains the following drugs: poria cocos, codonopsis pilosula, atractylodes atractylodes, tangerine peel, licorice root, coix seed and yam. The effects of Traditional Chinese Medicine and prescriptions are mainly spleen strengthening, dispelling dampness, clearing heat and promoting blood circulation.Conclusion:In the pathogenesis of colon polyp, spleen deficiency is the key point, and dampness, heat and stasis are the symptoms. The main treatment principles are invigorating spleen and removing dampness, with heat clearing and detoxification, activating blood circulation and removing stasis as supplement.

  大肠息肉是指大肠黏膜出现的赘生物，是一种肠道的良性肿瘤。可分为肿瘤性息肉和非肿瘤性息肉，前者癌变率高[1]，且早期无明显症状，随着疾病进展可出现腹痛、便血、腹泻等并发症，本病治疗以内镜下切除为主，但术后易复发，西医尚无明确有效预防其复发的办法，近年来，由于中医药可发挥多靶点作用，因此在预防大肠息肉复发方面取得了独特的疗效[2-4]，现对其规律总结如下。