社区早筛抗线粒体抗体阳性者的中医药早期干预效果分析

文章信息/Info

• Title:社区早筛抗线粒体抗体阳性者的中医药早期干预效果分析

• 卷期:2024年22卷13期

• 作者:刘贝1 罗志宇2  蒋式骊*3

• 1上海市徐汇区龙华街道社区卫生服务中心中医科 200232；2上海绿谷制药有限公司 201203，中国科学院上海药物研究所201210；3 上海中医药大学附属曙光医院肝病科 201203

• Author(s):LIU Bei1  LUO Zhi-yu2 Jiang Shi-li*3

• 1. Department of Traditional Chinese Medicine, Longhua Street Community Health Service Center, Xuhui District,Shanghai ,200232；2. Shanghai Greenvalley Pharmaceutical Co.,Ltd.201203, Shanghai Institute of MateriaMedica Chinese Academy of Sciences 201210；3 Hepatology Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,201203

• 关键词社区早筛；单纯抗线粒体抗体阳性者；中医体质辨识

• Keywords:community early screening; Patients with positive anti-mitochondrial antibody alone; TCM constitution identification

• 摘要:目的：探讨社区早筛抗线粒体抗体阳性者的中医药早期干预效果。方法:选取龙华、凌云、康健三个社区前期从二万例社区案例中筛查出的106例单纯抗线粒体抗体阳性者进中医药早期干预，随机分为研究组和对照组，每组53例，分析两组肝功能及中医体质辨识评分变化情况。结果: 治疗前两组肝功能检测结果无显著性差异（P>0.05），治疗后，与对照组相比，研究组总胆红素水平显著降低，两组差异显著（P<0.01）。运用《中医体质分类与判定》量表，治疗前两组体质分类和总体评分无显著差异（p>0.05）；治疗后体质变化没有明显差异，但研究组总体评分降低，其中最常发生的5种症状干燥、便秘、喜饮水、口苦、小便黄评分在研究组明显降低，两组差异显著（P<0.05）。结论：对社区早筛抗线粒体抗体阳性者进行中医药早期干预有利于改善不适症状，提高生存质量、值得进一步研究。                                                                                                                                                                                

• AbstractTo investigate the early intervention effect of traditional Chinese medicine in community early screening patients with positive anti-mitochondrial antibodies. Methods: 106 positive patients with simple anti-mitochondrial antibody were selected from 20,000 community cases in Longhua, Lingyun and Kangjian communities for early intervention of traditional Chinese medicine. They were randomly divided into study group and control group, with 53 cases in each group. The changes of liver function and TCM physique identification scores of the two groups were analyzed. Results: Before treatment, there was no significant difference in the liver function test results between the two groups (P>0.05). After treatment, compared with the control group, the level of total bilirubin in the study group was significantly decreased, and the difference between the two groups was After treatment, there was no significant difference in physical changes, but the overall score of the study group was decreased, among which the five most common symptoms of dryness, constipation, drinking, bitter mouth and yellow urine score were significantly decreased in the study group, and the difference between the two groups was significant (P<0.05). Conclusion: Early intervention of traditional Chinese medicine in community early screening patients with positive anti-mitochondrial antibodies is beneficial to improve the symptoms of discomfort and improve the quality of life, which is worthy of further research.

  原发性胆汁性肝硬化（primary biliary cirrhosis，PBC）是一种慢性自身免疫性肝内胆汁淤积性疾病，发病较多的群体为中年女性，主要表现为肝内小胆管的非化脓性炎症和破坏，肝实质碎屑状坏死以及门脉周围炎症[1]。控制该类肝硬化发展的最有效方法为早期发现并早期干预。对PBC发病早期的描述包括：血清抗线粒体抗体阳性、肝活检呈现PBC特性、没有肝病症状和肝功能异常[2]。