自拟连朴饮对幽门螺杆菌感染复治失败者的效果观察

文章信息/Info

• Title:自拟连朴饮对幽门螺杆菌感染复治失败者的效果观察

• 卷期:2024年22卷14期

• 作者:黄捷平

• 江西省中西医结合医院消化科  南昌  330003

• Author(s):Huang Jieping

• Digestive Department of Jiangxi Integrated Traditional Chinese and Western Medicine Hospital Nanchang 330003

• 关键词连朴饮 幽门螺杆菌复治 四联疗法

• Keywords:Lianpu Drink  Helicobacter pylori retreatment  Quadruple therapy

• 摘要:目的:观察自拟连朴饮联合标准四联疗法对幽门螺杆菌感染复治失败者的效果。方法：选取胃脘痛脾胃湿热型患者且既往幽门螺杆菌(Hp)感染杀菌失败者157例。其中对照组78例予以标准四联疗法杀灭Hp。随机分为治疗组(79例)和对照组(78例)。对照组予以标准四联疗法杀灭Hp。治疗组在对照组基础上加用自拟连朴饮,每组疗程均为14天。疗程结束30天后复查Hp。评估每组患者Hp根除率效果。结果：治疗组HP根除阳性率为79.7%,对照组阳性率为64.1%,治疗组较对照组效果更佳。结论：自拟连朴饮联合四联疗法根除Hp的疗效优于单纯四联疗法,根除率显著。为幽门螺杆菌感染复治失败者提供了一种新的临床疗法。                                                                                                                                                                                

• AbstractTo observe the effect of Lianpu decoction combined with standard quadruple therapy on the failed patients with Helicobacter pylori infection. Methods: 157 patients with epigastralgia, spleen stomach damp heat type and previous Helicobacter pylori (Hp) infection and sterilization failure were selected. 78 cases in the control group were treated with standard quadruple therapy to kill Hp. They were randomly divided into treatment group (79 cases) and control group (78 cases). The control group was treated with standard quadruple therapy to kill Hp. The treatment group added self-made Lianpu drink on the basis of the control group, and the course of treatment for each group was 14 days. Recheck Hp 30 days after treatment. Evaluate the effect of Hp eradication rate in each group. Results: The positive rate of HP eradication was 79.7% in the treatment group and 64.1% in the control group. The effect of the treatment group was better than that of the control group. Conclusion: The curative effect of self prepared Lianpu decoction combined with quadruple therapy in eradicating Hp is better than that of simple quadruple therapy, and the eradication rate is significant. It provides a new clinical therapy for the failed patients with Helicobacter pylori infection.

  幽门螺杆菌( Helicobacter pylori,H.pylori)是胃内常见致病菌，能在胃腔高酸性环境下长期生存[1]，并能侵入胃粘膜，通过释放毒素诱发炎症反应，破坏胃上皮细胞等致病。该菌与多种疾病相关已是公认的事实，它与胃炎，消化性溃疡及胃癌密切相关。而且与胃部息肉、结肠肿瘤、贫血、心血管疾病等也有一定相关[2]。hp感染为胃癌重要致癌因素。Hp在全球人群中的感染率在50%以上[3]。我国H. pylori感染率平均为56.22%处于世界平均水平[4]。