桂附苏朴汤治疗老年阳虚气逆型反流性咽喉炎疗效探究

文章信息/Info

• Title:桂附苏朴汤治疗老年阳虚气逆型反流性咽喉炎疗效探究

• 卷期:2024年22卷15期

• 作者:陆菁菁1 ，黄源鹏1，王敏1，庄璇1，李娜2

• 1.厦门市中医院老年病科  福建厦门 361000；2.厦门市集美区集美街道社区卫生服务中心  福建厦门 361021

• Author(s):Lu Jingjing1,Huang Yuanpeng1,Wang Min1,Zhuang Xuan1,Li Na2

• 1.Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361000,China;2.Jimei Street Community Health Service Centre, Jimei District, Xiamen 361012,China

• 关键词桂附苏朴汤；老年患者；阳虚气逆型；反流性咽喉炎

• Keywords:Guifusupu recipe;Elderly patients;Yang deficiency and qi inversion type;Laryngopharyngeal reflux disease

• 摘要:目的：探讨桂附苏朴汤治疗老年阳虚气逆型反流性咽喉炎的临床疗效。方法：对我院2020年11月至2022年5月间收治的58例老年阳虚气逆型反流性咽喉炎患者作出回顾性分析，据治疗方案的不同分为研究组29例与对照组29例。对照组采取西药常规治疗，研究组在前者基础上加予桂附苏朴汤治疗，对比两组患者的中医证候积分、总有效率及停药两周后的复发率。结果：治疗前，两组的中医证候积分比较差异无统计学意义（P>0.05）；经治疗后，两组的中医证候积分均存在一定程度的下降，但研究组证候积分相对于对照组更低（P<0.05）。研究组总有效率（96.55%）较对照组（79.31%）更高（P<0.05）。研究组复发率（3.57%）较对照组（25.93%）更低（P<0.05）。结论：桂附苏朴汤治疗老年阳虚气逆型反流性咽喉炎可获得较好的疗效，有利于缓解患者症状，复发率较低，安全性较好。                                                                                                                                                                                

• AbstractTo explore the clinical efficacy of Guifusupu Decoction in the treatment of laryngopharyngeal reflux disease (Yang deficiency and Qi inversion Type). Methods:A retrospective analysis of 58 elderly patients with laryngopharyngeal reflux disease (Yang deficiency and Qi inversion Type) admitted to our hospital from November 2020 to May 2022 was divided into study group(n=29) and control group(n=29) according to different treatment options. The control group took conventional treatment, and the study group was treated with Guifusupu Decoction and conventional treatment. The TCM syndrome score, total effective rate and recurrence rate of the two groups were compared. Results:Before treatment, there was no significant difference in the scores of medical syndromes between the two groups (P>0.05), after treatment, the scores of TCM syndromes of the two groups decreased to a certain extent, but the number of study components was lower than that of the control group (P<0.05). The total effective rate of the study group (96.55%) was higher than that of the control group (79.31%) (P<0.05). The recurrence rate of the study group (3.57%) was lower than that of the control group (25.93%) (P<0.05). Conclusion:Guifusupu Decoction has a better effect in the treatment of elderly laryngopharyngeal reflux disease (Yang deficiency and Qi inversion Type), which can further relieve the symptoms of patients with a lower recurrence rate and better safety.

  反流性咽喉炎（Laryngopharyngeal reflux disease，LPRD）在人群中的发病率非常高，系由于食管、胃内容物反流到咽喉部，刺激鼻咽、口咽及喉咽所导致的黏膜损伤性疾病，和上食管括约肌功能不良有关，临床表现多样：咽部异物感或吞咽不畅感、慢性咳嗽（多为刺激性干咳）、发音困难、声嘶、清嗓、咽痛、咽干、呼吸困难、口臭、咽部黏性分泌物增多等，纤维喉镜有相应的杓区及声带的特异表现。中医可根据其症状而相应归属于“喉痹”、“梅核气”、“吐酸”、“嘈杂”、“呃逆”等范畴。LPRD中大多为胃食管反流病(Gastroesophageal reflux disease，GERD)引起，有研究表明，在LPRD患者中，患有GERD高达34.6%[ ]，系过多胃、十二指肠内容物反流入食管引起的疾病，随年龄增长，食管下括约肌的紧张度逐渐下降而易发GERD，故LPRD发病率亦随老化而增加。