自拟中药方剂保留灌肠联合头孢呋辛钠治疗慢性盆腔炎临床观察

文章信息/Info

• Title:自拟中药方剂保留灌肠联合头孢呋辛钠治疗慢性盆腔炎临床观察

• 卷期:2024年22卷18期

• 作者:黄春萍

• 江西省上饶市广信区中医院妇产科   江西 上饶 334110

• Author(s):Huang Chunping

• Department of Obstetrics and Gynecology, Guangxin District Hospital of Traditional Chinese Medicine, Shangrao City, Jiangxi Province 334110

• 关键词慢性盆腔炎；自拟中药方剂；保留灌肠；头孢呋辛钠；炎性因子

• Keywords:Chronic pelvic inflammation; Self prepared traditional Chinese medicine prescriptions; Retention enema; Cefuroxime sodium; Inflammatory facto

• 摘要:目的  探究自拟中药方剂保留灌肠联合头孢呋辛钠治疗慢性盆腔炎的效果。方法  选取2018年6月—2021年4月江西省上饶市广信区中医院妇产科收治的80例慢性盆腔炎患者，根据随机数字表法分为对照组（40例）与试验组（40例）。对照组采用头孢呋辛钠治疗，试验组在对照组的基础上采用自拟中药方剂保留灌肠治疗，比较2组的治疗效果、中医证候积分、治疗前后炎性因子变化及不良反应发生率。结果  试验组治疗总有效率为95.00%（38/40），高于对照组的80.00%（32/40）（P＜0.05）。治疗后，试验组带下量多、腹胀下坠、腰骶部酸痛积分均低于对照组（P＜0.05）。治疗后，试验组肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C反应蛋白（CRP）水平均低于对照组（P＜0.05）。2组不良反应发生率比较差异无统计学意义（P＞0.05）。结论  自拟中药方剂保留灌肠联合头孢呋辛钠治疗慢性盆腔炎患者可加快临床症状消退，降低机体炎性因子水平，其治疗效果及安全性均显著，值得临床推广应用。                                                                                                                                                                                

• Abstract To investigate the effect of retention enema with self-made Chinese herbal formula combined with cefuroxime sodium on chronic pelvic inflammation. Methods From June 2018 to April 2021, 80 patients with chronic pelvic inflammatory disease were selected from the Department of Obstetrics and Gynecology, Guangxin District Hospital of Traditional Chinese Medicine, Shangrao City, Jiangxi Province, and divided into the control group (40 cases) and the test group (40 cases) according to the random number table. The control group was treated with cefuroxime sodium, and the test group was treated with retention enema of self prepared traditional Chinese medicine prescription on the basis of the control group. The treatment effect, TCM syndrome score, changes of inflammatory factors before and after treatment and the incidence of adverse reactions of the two groups were compared. Results The total effective rate of the experimental group was 95.00% (38/40), which was higher than 80.00% (32/40) of the control group (P<0.05). After treatment, the test group had a large amount of girdle, abdominal distension and sagging, and lumbosacral pain scores were lower than those in the control group (P<0.05). 

  慢性盆腔炎是临床常见妇产科疾病，主要指女性内生殖器以及其周围的结缔组织产生炎性病变形成的慢性炎症，通常可由感染因素或患者自身免疫因素引发[1]。发病后通常病程较长，可反复发作，并引起患者的腹部坠胀、腰骶酸痛、不孕等临床症状，需要及时对其展开针对性治疗，以此缓解炎症反应，消除症状表现[2-3]。临床常使用抗生素类药物对患者进行消炎治疗，如头孢呋辛钠，虽能够改善临床症状，但一旦停药病情易复发，无法达到根治效果。中西医结合治疗近年来被广泛用于妇科疾病中，通过辨证论治展开治疗。中药保留灌肠是通过患者直肠进行给药，充分利用人体肠道黏膜吸收能力，促进药物生效，以达到提升治疗效果目的[4]。