奥美拉唑联合自拟中药汤剂治疗胃溃疡的临床观察

文章信息/Info

• Title:奥美拉唑联合自拟中药汤剂治疗胃溃疡的临床观察

• 卷期:2024年22卷24期

• 作者:陈艳 徐晓平

• 乳山市中医院脾胃病科  山东威海  264500

• Author(s):Chen Yan and Xu Xiaoping

• Department of Spleen and Stomach Diseases, Rushan Hospital of Traditional Chinese Medicine, Weihai 264500, China

• 关键词奥美拉唑；自拟中药汤剂；胃溃疡；症状评分；炎症反应；病情复发

• Keywords: Omeprazole; Ziquasi TCM Decoction; gastric ulcer; Symptom scores; Inflammatory response; Condition recurred

• 摘要:目的：分析奥美拉唑联合自拟中药汤剂治疗胃溃疡的效果。方法：以2021年7月~2022年7月为观察时间段，此期间，入选了乳山市中医院的70例胃溃疡患者分析，入选者随机抽签后均分为两组，对照组以奥美拉唑治疗，观察组则联合自拟中药汤剂治疗，比较两组具体疗效。结果：在症状评分中，治疗前无组间差异，P＞0.05，治疗后，各数据在观察组评分较低，包含腹痛、胃灼热、反酸等几项，组间可见差异，P＜0.05；在黏膜组织细胞学评分中，治疗前，无组间差异，P＞0.05，治疗后，均表现为观察组评分低，包含炎性细胞浸润、炎症活动、腺体形态等基线，组间可见差异，P＜0.05；在Hp根除率和溃疡愈合率的比较中，观察组数据较高，P＜0.05；在Hp复发率和胃溃疡复发率的比较中，观察组数据较低，P＜0.05。结论：奥美拉唑联合自拟中药汤剂可以有效缓解胃溃疡患者病症，改善黏膜炎症，促进溃疡修复，同时抑制病情复发，值得使用。                                                                                                                                                                                

• Abstractto analyze the effect of omeprazole combined with ziquasi TCM Decoction on gastric ulcer. Methods: between July 2021 and July 2022 was used as the observation time period, during which, 70 patients with gastric ulcer who were admitted to the dairy Mountain hospital of traditional Chinese medicine were analyzed, and the enrollees were equally divided into two groups after random drawing, the control group was treated with omeprazole, and the observation group was treated with a combination of selfmimicking traditional Chinese medicine decoction to compare the specific efficacy of the two groups. Results: in symptom scores, there were no between group differences before treatment, P > 0.05, and after treatment, each data was scored lower in the observation group, containing several items, such as abdominal pain, heartburn, and regurgitation, with visible differences between groups, P < 0.05; In mucosal Histocytology scores, pre-treatment, no differences between groups, P > 0.05, and post-treatment, all showed low scores in the observation group, including inflammatory cell infiltration, inflammatory activity, and gland morphology at baseline, with differences seen between groups, P < 0.05; In the comparison of HP eradication rate and ulcer healing rate, the data in the observation group were higher, P < 0.05; In the comparison of HP recurrence rate and gastric ulcer recurrence rate, the data of the observation group were lower, P < 0.05. Conclusions: Omeprazole combined with a self mimicking Chinese herbal decoction can effectively alleviate the conditions of patients with gastric ulcer, improve mucosal inflammation, promote ulcer repair, while inhibiting disease recurrence, and is worth using.

  胃溃疡属于消化内科疾病，在临床中十分常见，本病的发病率约在10%左右，可导致餐后腹部胀满、胃痛、嗳气等病症，严重降低了患者的生活质量[1]。有学者认为，胃溃疡的发病和幽门螺杆菌感染（Hp感染）相关，但关于其具体的发病机制，临床尚无定论。现代医学研究则指出，本病的发病和胃酸分泌过多、黏膜损伤、胃蛋白酶分泌异常等多种因素相关[2]。